KLF4 and psoriasis: With respect to KCs, we identified an AP-1 motif enriched with respect to sequences near genes co-expressed with KLF4 (P = 2.3 × 10−3), and found that a linked psoriasis risk variant at rs7850481 (543 kb upstream of KLF4) abrogated a match to this motif (Additional file 16, Part E).