Recently, this viral response pathway emerged from a large-scale analysis of expression data, where it was designated as the “STAT1-57” regulon and shown to be activated in psoriasis lesions, cytokine-inducible (e.g., IFN-γ, IFN-α, TNF, IL-1α), and repressed in vivo by biologic therapies or glucocorticoids [65]. The gene discussed is TNF; the disease is psoriasis.