Application of ARACNE to the placental gene expression profiles of the largest available case-control study of preeclampsia fitting our selection criteria (i.e., tissue biopsy from fetal cell-derived histologic subsection of placenta) revealed GTF2E1 (component of TFIIE which modulates TFIIH) among major regulators of differentially-expressed genes in preeclampsia. This evidence concerns the gene ERCC2 and preeclampsia.