FLT1 and preeclampsia: In order to validate the finding of GTF2E1 as the regulator of the gene network altered in preeclampsia, we analyzed the Human Umbilical Vein Endothelial Cells (HUVEC) transcriptome dataset (GSE27871) [27] to compare the affected gene regulatory networks of GTF2E1 and FLT1 siRNA-inhibited umbilical cord endothelial cells.