Based on eight TTD [8,31,32]a and three XP [33-35]a cases with reported XPD mutations and explicit information on presence or absence of preeclampsia (many case reports and review articles on XP and TTD lacked explicit information on presence or absence of preeclampsia), we localized the preeclampsia-associated mutations to a C-terminal motif and the helicase surfaces of XPD. The gene discussed is ERCC2; the disease is preeclampsia.