Based on our findings that YB-1 suppresses the expression of Sox2 in BC, and the previous observation that ER-negative BC cell lines generally have a higher level of YB-1 activation (phosphorylation of YB-1 at serine 102) than ER-positive BC cell lines [22], we speculated that the expression level of Sox2 is higher in ER-positive BC cells. This evidence concerns the gene SOX2 and breast cancer.