PDPN and glioblastoma: Due to the coincidence of GAS5 expression with podoplanin immunoreactivity and the fact that GAS5 has been recently demonstrated to have miRNA sponge activity [23] one possibility is that high GAS5 expression is not only controlling cell cycle, but it is acting as miRNA natural sponge [46] to scavenge podoplanin mRNA degradation by miRNA, which is known to occur at least in glioblastoma [47].