Many investigators utilize diagnostic criteria for SS based on the revised American-European Consensus Group which include (1) ocular symptoms, (2) oral symptoms, (3) ocular signs, (4) focal sialoadenitis, (5) salivary gland involvement, (6) anti-Ro/La antibodies in the absence of head and neck radiation treatment, hepatitis C, AIDS, pre-existing lymphoma, sarcoidosis, graft versus host disease or anticholinergic drugs. This evidence concerns the gene CALR and lymphoma.