CALR and hepatitis C virus infection: The current diagnostic criteria for SS from the American College of Rheumatology requires three of four objective criteria or four of six total criteria that include: (1) ocular symptoms, (2) oral symptoms, (3) ocular signs, (4) focal sialoadenitis, (5) salivary gland involvement, (6) antinuclear antibodies (ANA), rheumatoid factor (RF), anti-Ro or anti-La autoantibodies in the absence of head and neck radiation treatment, hepatitis C, acquired immunodeficiency syndrome (AIDS), sarcoidosis, graft versus host disease or anticholinergic drugs [1].