treatment.Among these, only hsa-miR-26a-5p, which has been shown to be mainly expressed in neural tissue [14], showed the most significant expression change in IFN-β treated RRMS patients, at different therapy stages.MiR-26a-5p expression was significantly higher in IFN-β treated responder RRMS patients at 3 months treatment compared to the baseline, keeping quite stable at 6 months treatments (Figure 2). Here, IFNB1 is linked to relapsing-remitting multiple sclerosis.