Both C-type lectin receptors such as liver/lymph node-specific intercellular adhesion molecule-3-grabbing integrin (L-SIGN) or dendritic cell specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) [13, 14], as well as antibody-mediated infection may provide SARS-CoV with an opportunity to modify its tropism. This evidence concerns the gene CD209 and infection.