Since the role of PTPRJ in normal and malignant B-cell differentiation is poorly understood, we used pathway and genomic analyses to identify cellular pathways that may be altered by the inactivation of PTPRJ in order to provide a better understanding of the role of PTPRJ in the lymphomagenesis of FL and DLBCL. This evidence concerns the gene PTPRJ and diffuse large B-cell lymphoma.