CD4 and B-cell non-Hodgkin lymphoma: In addition, NFATC3 was hypothesized as being part of a mechanism whereby intratumoural CD4+CD25+ T-cells (Treg cells) interact with activated CD4+ T-cells to suppress the anti-tumour activity of infiltrated CD4+ T-cells in B-cell NHL tumours and thus, induce immune tolerance to these tumours [39].