SOX2 and colorectal carcinoma: Using a series of assays (for example, a reporter assay to validate that SOX2 is the only and direct target, miR-638 alterations drove SOX2 expression, miR-638 expression was inversely correlated with SOX2 expression in CRC tissues, SOX2 knockdown phenocopied the overexpression of miR-638, and SOX2 overexpression in miR-638-transfected cells rescued miR-638-induced function), SOX2 was finally identified as the functional target gene of miR-638 in CRC.