Moreover, the SOX2 protein expression levels were downregulated in the miR-638 mimic-transfected CRC cell lines compared with the negative control (mimics negative control), and SOX2 expression was upregulated in the antagomiR-transfected CRC cell lines compared with the negative control (antagomiR negative control; Figure 4E). The gene discussed is SOX2; the disease is colorectal carcinoma.