The results indicated that the SOX2 staining intensity values were upregulated in CRC tissue samples by 40.45% compared with those of the adjacent non-cancerous tissues (1.4045/1; the SOX2 IHC average intensity value in CRC samples was designated as 1) and in 86.67% of the samples (78/90; Figure 5D). Here, SOX2 is linked to colorectal carcinoma.