Furthermore, the inhibition of miR-638 induced CRC cell lines to develop mesenchymal-like cell features (e.g., reduced cell-cell contact, increased lamellipodium stretching, decreased expression of the epithelial cell marker ZO-1/E-cadherin, increased expression of the mesenchymal cell marker vimentin, and increased cell migration and invasion), and we confirmed that SOX2 is a direct target of miR-638. This evidence concerns the gene VIM and colorectal carcinoma.