Diabetic mice treated with insulin, as a positive control, showed obvious decreased glucose levels in all four weeks, as compared to other STZ-induced groups, and the reduction was significant in 4w compared NS mice (P < 0.05) (Figure 3a).Cytisine and Trolox C were also evaluated for intraperitoneal glucose tolerance (IPGTT) and total area under the curve (AUC) for glucose tolerance. This evidence concerns the gene INS and glucose measurement.