However, a significantly more IL-17RC+ cells can be found in the cultures of CD8+ T cells stimulated by anti-CD3/anti-CD28 antibodies as compared to the unstimulated whole blood test, suggesting that during active inflammation, IL-17RC+CD8+ T cells might be activated by local antigen in the eye, which might contribute to the formation of granulomas in sarcoidosis patients. The gene discussed is CD28; the disease is Granuloma.