As Cebpb is relevant to expression of Runx2 [18-21] which has been known a determinant of CCD [6], consistency between murine phenotypes of Cebpb deficiency and human manifestations of RUNX2 insufficiency implies a potential effect of Cebpb on occurrence of CCD in mice. This evidence concerns the gene RUNX2 and cleidocranial dysplasia 1.