The human AML cell line MOLM-13 (TP53 wild type) treated with nutlin-3 at increasing time points demonstrated increased levels of p53, MDM2, p21 and acetylated p53 (Lys382), while the induction of phosphorylated p53 (Ser15 and Ser20) was diminishable (Figure 1A). Here, MDM2 is linked to acute myeloid leukemia.