KRAS and colorectal cancer: For cases with the 10 most common KRAS mutations across all four codons examined, those with the c.34G>T (p.G12C) mutation, and those with the c.35G>T (p.G12V) mutation experienced significantly higher colorectal cancer-specific mortality in Cox regression analysis [multivariate HR = 2.33; 95% CI, 1.36-3.99; P = 0.0021 for c.34G>T (p.G12C); multivariate HR = 2.13; 95% CI, 1.47-3.09; P < 0.0001 for c.35G>T (p.G12V); Table 3], even after adjusting a statistical significance level for multiple testing (P < 0.005).