Given that over 250,000 individuals each year die of colorectal cancer in Europe and the U.S., and most of these unfavorable outcomes are due to distant metastases, we estimate that every year approximately 10,000 cases have KRAS mutations in codon 61 or 146, and would be regarded as KRAS-wild-type through current KRAS codon 12 and 13 testing protocols. The gene discussed is KRAS; the disease is colorectal cancer.