Our data, from 1267 tumors, suggest that approximately 5% of all colorectal cancers harbor KRAS mutations in codon 61 or 146, and those colorectal cancers generally show similar characteristics to tumors with KRAS mutations in codon 12 or 13 (including associations with cecal location, CIMP-low and PIK3CA mutations). Here, KRAS is linked to colorectal cancer.