These results align with findings that soluble RCAS1 in serum is significantly increased in colon cancer patients compared with that in healthy individuals; higher concentration of soluble RCAS1 is significantly associated with advanced Dukes’ stage and high histopathological tumor grade; colon cancer patients with the higher concentration had significantly shorter overall survival time; and soluble RCAS1 is an independent prognostic factor for this malignancy[33,34]. This evidence concerns the gene EBAG9 and malignant colon neoplasm.