Furthermore, SCUBE2 serves two different functions by using either the CUB domain at the C-terminal end or the EGF-like repeats at the N-terminus, i.e. control of cell proliferation by antagonizing bone morphogenetic protein (BMP) activity and regulation of cell-cell contacts, and possibly tumor metastasis, by forming complexes with E-cadherin in adherens junctions, respectively [54]. Here, SCUBE2 is linked to neoplasm.