Interestingly, all 12 patients with SCUBE2-positive tumors were long-term disease-specific survivors and only 1/12 tumors had metastasized to the cervical lymph nodes.These findings are consistent with reports in breast carcinoma where elevated levels of the SCUBE2 protein not only inhibited proliferation of breast cancer cell lines, but was indicative of a more favorable prognosis [23,51]. The gene discussed is SCUBE2; the disease is breast cancer.