Here, we show the prognostic potential of the S100A8 and CNTNAP2 proteins, as well as the relationship between SCUBE2, CBX2, and STK32B protein levels and important clinicopathological features for OSCC, i.e. regional metastasis to the cervical lymph nodes, tumor inflammatory infiltration, and tumor size, respectively. The gene discussed is S100A8; the disease is neoplasm.