Many tumours and cell lines have activated Mnk1/2 signalling as well as cytoplasmic Cx43 expression, and it will be of interest to explore whether inhibition of Mnk1/2 in a cancer setting induces GJA1-20k expression, thereby enhancing the membrane targeting of full-length Cx43, as already indicated after mTOR inhibition by Smyth and Shaw [13]. Here, MTOR is linked to cancer.