This scenario may be plausible given that estimates of the annual incidence of GIST may rise with improved diagnosis of tumours that are tested for c-KIT.[22] Because a new effective treatment line would prolong life in the third-line treatment-eligible GIST and therefore increase prevalence, it was important to assess the longer patient survival impact on the third-line treatment-eligible GIST prevalence. This evidence concerns the gene KIT and neoplasm.