LDHA and lung cancer: The profound effect of DEAB in the cell viability of ALDHhigh fractions is supported by the findings which showed that the downregulation of ALDH isozymes in A549 lung cancer cell line altered cell proliferation and motility, whereas an analogous experiment in cell lines devoid of ALDH-expressing cells had an insignificantly less inhibitory effect on cell proliferation demonstrating a functional role of ALDH in the regulation of cell growth [9].