The crucial role of radioiodide-based therapy in thyroid cancer and the characterization of the molecular basis of iodide transport following the cloning of NIS, including its detection in some extrathyroidal tissues, has encouraged a large series of studies aimed to try to extend radioiodine treatment even to extrathyroidal tumors after induction of NIS expression. Here, SLC5A5 is linked to thyroid gland carcinoma.