It has been reported that the EGFR-TKI plus concomitant WBRT may have synergy effect in brain metastases from NSCLC, the ORR, ICR, and IC-PFS were significantly higher in gefitinib plus WBRT compared with gefitinib alone (ORR: 64.4% VS. 26.7%, P < 0.001; DCR: 71.1% VS. 42.2%, P = 0.006; IC-PFS: 10.6 months VS. 6.57 months, P < 0.001)[35]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.