The six-month, one-year, and two-year IC-PFS rates were 62.1%, 41.4%, and 10.3%, respectively (Figure 3).In univariate analysis, female, adenocarcinoma, Score Index for Radiosurgery in Brain Metastases (SIR) score >5, number of intracranial lesions <3, total volume of intracranial lesions <7 cc, and history of EGFR-TKI treatment were significant predictors for better OS and IC-PFS(see Table 2). Here, EGFR is linked to adenocarcinoma.