After B16-OVA-GFP, B16-OVA-USP18, or B16-OVA-shUSP18 tumor cells were subcutaneously inoculated into C57BL/6 mice, tumor growth in mice receiving B16-OVA-USP18 cells was significantly inhibited, whereas tumor growth was promoted in those receiving B16-OVA-shUSP18 tumor cells (Figure 2G). This evidence concerns the gene USP18 and neoplasm.