The administration of 10 mg/kg bevacizumab for 3 weeks resulted in a significant increase in invasive tumor cells outside the tumor rim, visualized by vimentin staining (Figure 3), suggesting that anti-VEGF treatment induced an increased ability of cell migration and invasion both in cultured C6 cells and in intracranial C6 glioma cell xenograft. Here, VIM is linked to neoplasm.