However, in the tumor microenvironment, elevated infiltration of FOXP3+ Tregs was correlated with a favorable clinical outcome in different types of lymphoma reported, including DLBCL[29-33], and Hasselblom S et al. reported that DLBCL patients with a small number of cytotoxic T-cell intracytoplasmic antigen-1 (TIA-1) + T cellshad significantly better outcome[34]. This evidence concerns the gene FOXP3 and neoplasm.