SPP1 and Hepatic fibrosis: We observed, in 8 weeks, an increase in liver TG, fatty acid trafficking, inflammation and fibrosis, which was in consistence with earlier findings where the increase in gene expression of FABP4 (marker of fatty acid trafficking), osteopontin (marker of inflammation), COL1A1 and TIMP1 (markers of fibrosis) [40,41], which have been reported and duration for appearance of liver fibrosis was 24 weeks.