Brandes et al. [12] found that, in 79 patients with recurrent GBM treated with radiation plus daily TMZ followed by metronomic TMZ, distant recurrence (outside the radiation field) occurred in 21.5% of patients, while recurrence within or at the radiotherapy margin occurred in 85% of patients with MGMT unmethylated promoters and 57.9% of patients with MGMT methylated promoters. Here, MGMT is linked to glioblastoma.