YAP partially abolished the inhibiting effect of Fbxw7 on HCC growth; it led to a significant reduction in the number of apoptotic cells and increased the number of cells staining positive for Ki-67, which is consistent with our in vitro observations (P < 0.05 or P < 0.01, respectively, Figure 7B). Here, MKI67 is linked to hepatocellular carcinoma.