In unadjusted analysis an estimated gain in median OS of nine months was seen in the doublet arm compared to the monotherapy arm for patients with a TIMP-1 negative tumor (GD, median OS: 19.9 months, 95% CI = 14.5-28.5; D, median OS: 10.6 months, 95% CI = 7.9-16.5, log rank p = 0.053) (Figure 3A). Here, TIMP1 is linked to neoplasm.