MSH2 and breast cancer: We also evaluated the presence of the CHEK2 1100delC and TP53 R337H variants via sequencing and used array comparative genomic hybridization (array-CGH) to investigate CNVs in 14 additional breast cancer-predisposing genes: PTEN, ATM, NBN, RAD50, RAD51, BRIP1, PALB2, MLH1, MSH2, MSH6, TP53, CDKN2A, CDH1 and CTNNB1.