RHD and rheumatic heart disease: Körmöczi and colleagues suggested that the DEL phenotypes might be subdivided into two groups, partial DEL with characteristic D epitope loss caused by either RHD-CE-D hybrid genes or RHD point mutation such as carrier of RHD (IVS3 + 1G > A) affecting extracellular RhD loops and complete DEL where the majority of D epitopes are conserved such as RHD1227A[16].