CD163 and neoplasm: Furthermore, the expression of CD163 in OSCC was mainly observed in the cytoplasm and the mean expression scores were 18.33 ± 1.29, 5.14 ± 0.52, and 4.80 ± 0.53 in OSCC, oral epithelial dysplasia, and normal oral mucosa, respectively; however, the difference between CD163 staining in the tumor and normal oral mucosa was not significant (P > 0.05, Figure 1(b)).