Interestingly, when compared using multivariate analysis, only the current GE-based risk score and NRIP1 and TCF7 expression, kept prognostic value. NRIP1 gene, known as RIP140, is a nuclear receptor coregulator with important role in energy homeostasis and a potential involvement in breast cancer [23, 32]. The gene discussed is NRIP1; the disease is breast cancer.