Interestingly, GSEA analysis highlighted a significant enrichment of genes downregulated in CLL patients with mutated IgVH chain and genes upregulated in CLL patients expressing high levels of lipoprotein lipase in tumor cells of patients within high risk GE-based score group (Supplementary Figure S2 and Supplementary Tables S1 and S2), in particular already known bad prognosis factors LPL, DMD, AKAP12, and SEPT10 (Supplementary Table S2) [31]. This evidence concerns the gene SEPTIN10 and B-cell chronic lymphocytic leukemia.