In univariate analysis, Binet stage (P < 0.0001), the presence of ATM (P < 0.0001) and p53 (P = 0.0001) mutations and the presence of bulky lymphadenopathy (P = 0.0113) and B symptoms (P = 0.0045) were adversely correlated with OS. This evidence concerns the gene TP53 and Lymphadenopathy.