In the present study, we aimed for the first time to evaluate immunohistochemically the tissue levels of proangiogenic factors, that is, VEGF, IL-6, IL-8 along with IL-8 receptor CXCR2, tyrosine p-STAT-3, and SOCS-3 in the lymph nodes, in a series of patients with CLL/SLL. Here, STAT3 is linked to B-cell chronic lymphocytic leukemia.