AR and ischemia: Interestingly, as this seems to be the end of the story, this laboratory went further and demonstrated that formation of AR–SOH on cysteine 298 during cardiac ischemia reperfusion could be reversed back to AR–SH [129], which involved two enzymes, glutathione S-transferase converting AR–SOH to AR–SSG, and glutaredoxin converting AR–SSG to AR–SH [129].