In the multiple stepwise logistic regression analysis, participants in the higher quartiles for fractalkine had higher OR for the development of MetS and its components by year 2.Table 5 (model 2) showed that, compared with the lowest quartile of fractalkine concentration, the ORs in the highest quartile were 7.18 (95% CI: 2.28–18.59) for MetS, 4.83 (95% CI: 2.09–11.19) for central obesity, 1.03 (95% CI: 0.55–1.93) for elevated BP, 3.61 (95% CI: 1.63–8.02) for hyperglycemia, 2.63 (95% CI: 1.30–5.34) for hypertriglyceridemia, and 1.59 (95% CI: 0.60–4.24) for low HDL-c. The gene discussed is CX3CL1; the disease is Hyperglycemia.