ABCB1 and familial pancreatic carcinoma: The ABCB1 2677TT-3435TT haplotype was significantly associated with reduced risk of developing pancreatic cancer (OR 0.27, 95% CI 0.08 to 0.92, P = 0.037) in European Americans, and the expression of ABCB1 was also lower compared to the other haplotypes (Figure 3).