Despite the explanation offered in this paper that the generation of IFN-γ+ Th17 cells may be a direct consequence of a Th1-polarized cytokine milieu on Th17 cells, they may still represent a pathogenic subset of Th17 cells, and further characterization of these cells may provide a target for therapy and provide additional clues to the complex immunopathology of sarcoidosis. This evidence concerns the gene IFNG and sarcoidosis.