Comparison of all cases with all control subjects showed no significant difference in FLG mRNA levels (P > .05), but there is significantly greater mRNA expression in wild-type AD cases than wild-type control subjects (P = 3.0 × 10−3), suggesting that there might be a compensatory upregulation of FLG mRNA in atopic skin of FLG wild-type subjects. This evidence concerns the gene FLG and Alzheimer disease.