The signal transducer and activator of transcription (STAT) encoded by STAT1 contributes to the transcriptional control of several interferon-stimulated genes, including IFITM1, IFITM2, IFI27, and GBP1. The Janus kinase/STAT signaling pathway plays a key role in transmembrane signaling from the TH2 cytokines IL-4 and IL-13, which predominate in acute AD.56 Here, IFI27 is linked to Alzheimer disease.