The chemokine network encoded by genes including CCL13, CCL18, CXCL9, and CXCL10 has been implicated in the pathogenesis of AD in some of the previous microarray studies.9,11,13,58 Filaggrin haploinsufficiency increases the risk of eczema herpeticum,59 and the functional network predicted by transcriptomic analysis indicates a pathway that might be targeted for therapeutic intervention in susceptible patients. This evidence concerns the gene CCL18 and herpes simplex dermatitis.