IFITM1 and IFITM2 encode interferon-induced transmembrane proteins, which contribute to the control of cell growth through a multimeric complex involved in the transduction of antiproliferative and homotypic adhesion signals; they are induced by IFN-γ in primary keratinocytes in vitro and have been proposed to play a role in keratinocyte apoptosis in patients with AD.57 This evidence concerns the gene IFITM2 and Alzheimer disease.