Utilizing a previously described cohort of 458 individuals with hypertriglyceridemia (defined as fasting plasma triglyceride levels above the 95th percentile) and 333 control individuals with normal plasma triglyceride levels, 30 individuals (24 cases, 6 controls) harboring a total of 18 rare (minor allele frequency <0.01) GCKR variants were identified by targeted exon sequencing (8). Here, GCKR is linked to hypertriglyceridemia.