Preoperative factors predictive of responsive outcome of typical GERD symptoms to TF by multivariate analysis were age ≥ 50 years (OR = 2.6, CI = 1.2–5.7, p = 0.018) and the presence of esophagitis (OR = 2.9, CI = 1.3–6.3, p = 0.008), Table 3. The gene discussed is TF; the disease is esophagitis.