TNFRSF21 and neoplasm: However, the unexpected increase in the expression of genes related to apoptosis, such as members of the superfamily of tumor necrosis factor receptors (TNFRSF10A, TNFRSF10D, TNFRSF21, and TNFRSF12A), as well as the downregulation of the anti-apoptotic gene BCL2, suggest that contradictory forces are playing key roles in the balance of tumor growth in high-CN tumors.