EZH2 and neoplasm: Interestingly, Ezh2 is known to be up-regulated in activated lymphocytes and play an essential role in this process (59, 60),3 and it would be interesting to examine the role of Ezh2 in the context of microglia activation, which contributes to pathogen clearance in health or the progression of neurodegenerative and neoplastic diseases (61).