Hence, we studied the transcriptional status of p53 gene and observed decreased levels of p53 mRNA in Al(mal)3 treated cells as compared to control (Figure 6D) indicating that p53 is transcriptionally suppressed in response to Al treatment and plays no positive role in mediating Al induced apoptosis of SH-SY5Y human neuroblastoma cells. Here, TP53 is linked to neuroblastoma.