We next investigated the role of the Smad3/TGFβ signaling pathway by analyzing a specific mCherry reporter driven by Smad3 responsive elements; Smad3 is reported to be activated in pancreatic adenocarcinoma as a response to the antiproliferating function of TGFβ (Ungefroren et al., 2011). Here, SMAD3 is linked to pancreatic adenocarcinoma.