Besides a significant increase in p53 onco-suppressor and TGFβR1 mRNA inside the eGFP-KRASG12D-positive tumor mass (Fig. 6C), other pathways were directly or indirectly involved in pancreatic tumor progression: Notch and Wnt pathway activities increased at later stages of pancreatic tumor, as demonstrated by a significant increase in notch1a, her9, myc and cyclinD1 mRNA levels (Fig. 6D,E). Here, TP53 is linked to pancreatic neoplasm.