During carcinogenesis, Shh and Notch pathways seem to be involved in tumor onset, together with genomic instability, whereas Wnt and TGFβ appear activated in cancer progression by eliciting cell migration or neo-angiogenesis through reciprocal cross-talk or by interactions with other pathways (McCleary-Wheeler et al., 2012). This evidence concerns the gene TGFB1 and neoplasm.