SMAD3 and cancer: In other words, by comparing pancreatic adenocarcinoma with medulloblastoma, we were able to postulate that Smad3/TGFβ and Notch activities might be linked to the constitutive activation of KRASG12D, the activity of Smad3/TGFβ and Notch reporters being present in KRASG12D-expressing cells in both types of cancer.