Subsequent unbalanced expression of several genes such as P53, STAT3 (Corcoran et al., 2011), SMAD4 and ARF/INK4 (Aguirre et al., 2003) brings carcinoma in situ and, further, to metastatic carcinoma (Bardeesy et al., 2006). The gene discussed is CDKN2A; the disease is cancer.