Further, we found the upregulation of PCNA and p53 (Figs 3, 4, 6), demonstrating the cell hyperproliferation at the tumor site, a feature already reported in mouse and human tumors (Conradt et al., 2012; Ghosh and Leach, 2011; Gironella et al., 2007). Here, TP53 is linked to neoplasm.