The human pancreatic adenocarcinoma Capan-1 and MDAPanc-28 ST3Gal III transfected cells have been shown to exhibit a reduced cell-cell aggregation capacity and a high migration and invasion capability when compared with their respective mock cells, which is in agreement with our previous works reporting their increased migration through collagen and in vivo metastatic potential in mice [23], [30]. The gene discussed is ST3GAL3; the disease is pancreatic adenocarcinoma.