In previous studies we have described that α2,3-sialyltransferase ST3Gal III transfection of pancreatic adenocarcinoma cell lines Capan-1 and MDAPanc-28 leads to the overexpression of SLex antigen and the decrease of α2,6-sialic acid in their cell surface. The gene discussed is ST3GAL3; the disease is pancreatic adenocarcinoma.