Whereas in some studies [13, 14] high tissue levels of uPA, uPAR, and/or PAI-1 protein have been shown to be significantly associated with clinical prognostic parameters (GS, tumor stage, lymph node status, and tumor resection status), others did not find significant associations between high immunoexpression of uPA system components and clinicopathological parameters [15]. Here, SERPINE1 is linked to neoplasm.