SOD1 and amyotrophic lateral sclerosis: As misfolded SOD1 has been shown to play a major role in ALS MN degeneration by inducing ER stress [40, 41], the microvacuolization that we found in DRG neurons should be understood as a consequence of misfolded SOD1-induced ER stress in a type of neuron which is not usually considered a main target in ALS.