Shortly after cerebral vascular accident, local ischemia would lead to the destruction of neurons in the ischemic core and peri-infarct zone, resulting in the release of various DAMPs including high mobility group protein B1 (HMGB1), uric acid, heat shock proteins, S100 proteins, DNA, and RNA, which attract and activate neighboring microglia [8] and thereby trigger the postischemic inflammatory cascade. The gene discussed is HMGB1; the disease is ischemia.