Pendred syndrome is a recessive autosomal disorder characterized by thyroid goiter and sensorineural hearing loss due to mutations in the gene that encodes pendrin, which is an apical cortical collecting duct chloride/bicarbonate exchanger that manages the secretion of bicarbonate into the tubule lumen in exchange for chloride reabsorption [37–40]. The gene discussed is SLC26A4; the disease is Pendred syndrome.