However, our previous findings suggest an indirect evidence concerning these consequences: in rat carotid, type I-diabetes shifts the Gaussian-like shape of angiotensin II-evoked contraction curve into a sigmoidal shape, due to endothelial AT1-activated NAD(P)H oxidase-driven generation of superoxide (O2−), hydrogen peroxide (H2O2), and hydroxyl radical (∙OH) [8]. This evidence concerns the gene AGTR1 and type 1 diabetes mellitus.